Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens

Understand

Many biological discovery problems require experiments to be selected sequentially under constrained budgets.

• CRISPR screening is a prominent example, as exhaustive perturbation testing is often infeasible and candidate perturbations must instead be prioritized over multiple experimental rounds.
• Despite the importance of this problem, existing benchmarks for adaptive hit discovery remain limited in scale and diversity.
• Here, we introduce AssayBench-Loop, a large-scale benchmark for adaptive hit discovery comprising 1,389 CRISPR screens across five phenotype categories.