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Scientific discovery is driven by the iterative process of background research, hypothesis generation, experimentation, and data analysis.
Rank Analysis of Incomplete Block Designs: I. The Method of Paired Comparisons
Ralph Allan Bradley and Milton E. Terry · 1952
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Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines
P. Sauerberg, P. H. Olesen, S. Nielsen, S. Treppendahl, M. J. Sheardown, T. Honoré, C. H. Mitch, J. S. Ward, A. J. Pike, and F. P. Bymaster · 1992
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Arpe-19, a human retinal pigment epithelial cell line with differentiated properties
K.C. DUNN, A.E. AOTAKI-KEEN, F.R. PUTKEY, and L.M. HJELMELAND · 1996
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Signaling from rho to the actin cytoskeleton through protein kinases rock and lim-kinase
Midori Maekawa, Toshimasa Ishizaki, Shuken Boku, Naoki Watanabe, Akiko Fujita, Akihiro Iwamatsu, Takashi Obinata, Kazumasa Ohashi, Kensaku Mizuno, and Shuh Narumiya · 1999
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Antidepressant effects of ketamine in depressed patients
R. M. Berman, A. Cappiello, A. Anand, D. A. Oren, G. R. Heninger, D. S. Charney, and J. H. Krystal · 2000
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Apolipoprotein e allele-dependent pathogenesis: A model for age-related retinal degeneration
G. Malek, L. V. Johnson, B. E. Mace, P. Saloupis, D. E. Schmechel, D. W. Rickman, C. A. Toth, P. M. Sullivan, and C. Bowes Rickman · 2005
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Mln120b, a novel iκb kinase βinhibitor, blocks multiple myeloma cell growth in vitro and in vivo
Teru Hideshima, Paola Neri, Pierfranchesco Tassone, Hiroshi Yasui, Kenji Ishitsuka, Noopur Raje, Dharminder Chauhan, Klaus Podar, Constantine Mitsiades, Lenny Dang, and et al · 2006
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Damage-Induced Activation of ERK1/2 in Cochlear Supporting Cells Is a Hair Cell Death-Promoting Signal That Depends on Extracellular ATP and Calcium
Manuela Lahne and Jonathan E. Gale · 2008
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Folate Receptor Autoimmunity and Cerebral Folate Deficiency in Low-Functioning Autism with Neurological Deficits
V. T. Ramaekers, N. Blau, J. M. Sequeira, M.-C. Nassogne, and E. V. Quadros · 2008
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Allogeneic serum eye drops for the treatment of persistent corneal epithelial defect
C-C Chiang, W-L Chen, J-M Lin, and Y-Y Tsai · 2008
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The Role of Akt-GSK-3βSignaling and Synaptic Strength in Phencyclidine-Induced Neurodegeneration
Gang Lei, Yan Xia, and Kenneth M. Johnson · 2008
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Clinical Trials register - Search for 2009-015297-36
2009
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Forecasting Age-Related Macular Degeneration Through the Year 2050: The Potential Impact of New Treatments
David B. Rein, John S. Wittenborn, Xinzhi Zhang, Amanda A. Honeycutt, Sarah B. Lesesne, Jinan Saaddine, and Vision Health Cost-Effectiveness Study Group · 2009
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Immunomodulatory drug FTY720 induces regulatory CD4+CD25+ T cells in vitro
P J Zhou, H Wang, G H Shi, X H Wang, Z J Shen, and D Xu · 2009
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In vitro induction of T cells that are resistant to A2 adenosine receptor-mediated immunosuppression
Akio Ohta, J Kjaergaard, S Sharma, M Mohsin, N Goel, M Madasu, E Fradkov, Akiko Ohta, and M Sitkovsky · 2009
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Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt
Steffen Durinck, Paul T. Spellman, Ewan Birney, and Wolfgang Huber · 2009
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A Phase II (BRF113710) Single-arm, Open-label Study of GSK2118436 in BRAF Mutant Metastatic Melanoma
GlaxoSmithKline · 2010
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BRAF targeted therapy changes the treatment paradigm in melanoma
Antoni Ribas and Keith T. Flaherty · 2011
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Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2
Anika E. Wagner, Christine Boesch-Saadatmandi, Dorothea Breckwoldt, Charlotte Schrader, Constance Schmelzer, Frank Döring, Koji Hashida, Osamu Hori, Seiichi Matsugo, and Gerald Rimbach · 2011
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Analysis of photoreceptor outer segment phagocytosis by rpe cells in culture
Yingyu Mao and Silvia C. Finnemann · 2012
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Identification of Small Molecule Activators of Cryptochrome
Tsuyoshi Hirota, Jae Wook Lee, Peter C. St. John, Mariko Sawa, Keiko Iwaisako, Takako Noguchi, Pagkapol Y. Pongsawakul, Tim Sonntag, David K. Welsh, David A. Brenner, Francis J. Doyle, Peter G. Schultz, and Steve A. Kay · 2012
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Cerebral folate receptor autoantibodies in autism spectrum disorder
R E Frye, J M Sequeira, E V Quadros, S J James, and D A Rossignol · 2013
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Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
Kai Kaarniranta, Sinha , Debasish, Blasiak , Janusz, Kauppinen , Anu, Veréb , Zoltán, Salminen , Antero, Boulton , Michael E., , and Goran Petrovski · 2013
Cited alongside, same era.
β-Ionone attenuates LPS-induced pro-inflammatory mediators such as NO, PGE2 and TNF-αin BV2 microglial cells via suppression of the NF-κB and MAPK pathway
Chang-Hee Kang, Rajapaksha Gendara Prasad Tharanga Jayasooriya, Yung Hyun Choi, Sung-Kwon Moon, Wun-Jae Kim, and Gi-Young Kim · 2013
Cited alongside, same era.
Activation of HER3 Interferes with Antitumor Effects of Axl Receptor Tyrosine Kinase Inhibitors: Suggestion of Combination Therapy
Robert Torka, Kinga Pénzes, Simone Gusenbauer, Christine Baumann, István Szabadkai, Lászlo Őrfi, György Kéri, and Axel Ullrich · 2014
Cited alongside, same era.
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Michael I. Love, Wolfgang Huber, and Simon Anders · 2014
Cited alongside, same era.
Big Data: Astronomical or Genomical?
Rapamycin inhibits oral cancer cell growth by promoting oxidative stress and suppressing ERK1/2, NF-κB and beta-catenin pathways
Abdelhabib Semlali, Sofia Papadakos, Camille Contant, Ikram Zouaoui, and Mahmoud Rouabhia · 2022
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Autonomous chemical research with large language models
Daniil A. Boiko, Robert MacKnight, Ben Kline, and Gabe Gomes · 2023
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The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy
Zhibo Si, Yajuan Zheng, and Jing Zhao · 2023
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React: Synergizing reasoning and acting in language models, Mar 2023
Shunyu Yao, Jeffrey Zhao, Dian Yu, Nan Du, Izhak Shafran, Karthik Narasimhan, and Yuan Cao · 2023
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Histone Methyltransferases as a New Target for Epigenetic Action of Vorinostat
Varvara Maksimova, Julia Makus, Valeriia Popova, Anzhelika Prus, Olga Usalka, Ekaterina Trapeznikova, Ekaterina Zhidkova, Gennady Belitsky, Marianna Yakubovskaya, and Kirill Kirsanov · 2023
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Zachary D. Stephens, Skylar Y. Lee, Faraz Faghri, Roy H. Campbell, Chengxiang Zhai, Miles J. Efron, Ravishankar Iyer, Michael C. Schatz, Saurabh Sinha, and Gene E. Robinson · 2015
Cited alongside, same era.
The effect of ama0428, a novel and potent rock inhibitor, in a model of neovascular age-related macular degeneration
K. Hollanders, T. Van Bergen, N. Kindt, K. Castermans, D. Leysen, E. Vandewalle, L. Moons, and I. Stalmans · 2015
Cited alongside, same era.
Y-27632, a ROCK Inhibitor, Promoted Limbal Epithelial Cell Proliferation and Corneal Wound Healing
Chi-Chin Sun, Hsiao-Ting Chiu, Yi-Fang Lin, Kuo-Ying Lee, and Jong-Hwei Su Pang · 2015
Cited alongside, same era.
Rock inhibitors in ocular disease
Eva Halasz and Ellen Townes-Anderson · 2016
Cited alongside, same era.
AICAR suppresses TNF-α-induced complement factor B in RPE cells
Eun Jee Chung, Nikolaos E. Efstathiou, Eleni K. Konstantinou, Daniel E. Maidana, Joan W. Miller, Lucy H. Young, and Demetrios G. Vavvas · 2017
Cited alongside, same era.
RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells
George Inana, Christopher Murat, Weijun An, Xiang Yao, Ian R. Harris, and Jing Cao · 2018
Cited alongside, same era.
Inhibiting focal adhesion kinase (FAK) blocks IL-4 induced VCAM-1 expression and eosinophil recruitment in vitro and in vivo
Gurpreet K. Aulakh, Björn Petri, Katarzyna M. Wojcik, Pina Colarusso, James J. Lee, and Kamala D. Patel · 2018
Cited alongside, same era.
Rock inhibitor-induced promotion of retinal pigment epithelial cell motility during wound healing
Hiroyuki Kamao, Atsushi Miki, and Junichi Kiryu · 2019
Cited alongside, same era.
LLMs4Synthesis: Leveraging Large Language Models for Scientific Synthesis, September 2024
Hamed Babaei Giglou, Jennifer D’Souza, and Sören Auer · 2024
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Using GPT-4 to write a scientific review article: a pilot evaluation study
Zhiping Paul Wang, Priyanka Bhandary, Yizhou Wang, and Jason H. Moore · 2024
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The AI Scientist: Towards Fully Automated Open-Ended Scientific Discovery, September 2024
Chris Lu, Cong Lu, Robert Tjarko Lange, Jakob Foerster, Jeff Clune, and David Ha · 2024
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Autonomous LLM-driven research from data to human-verifiable research papers, April 2024
Tal Ifargan, Lukas Hafner, Maor Kern, Ori Alcalay, and Roy Kishony · 2024
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Tx-LLM: A Large Language Model for Therapeutics, June 2024
Juan Manuel Zambrano Chaves, Eric Wang, Tao Tu, Eeshit Dhaval Vaishnav, Byron Lee, S. Sara Mahdavi, Christopher Semturs, David Fleet, Vivek Natarajan, and Shekoofeh Azizi · 2024
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Language agents achieve superhuman synthesis of scientific knowledge, September 2024
Michael D. Skarlinski, Sam Cox, Jon M. Laurent, James D. Braza, Michaela Hinks, Michael J. Hammerling, Manvitha Ponnapati, Samuel G. Rodriques, and Andrew D. White · 2024
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Age-related macular degeneration
Monika Fleckenstein, Steffen Schmitz-Valckenberg, and Usha Chakravarthy · 2024
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Open targets platform: facilitating therapeutic hypotheses building in drug discovery
Annalisa Buniello, Daniel Suveges, Carlos Cruz-Castillo, Manuel Bernal Llinares, Helena Cornu, Irene Lopez, Kirill Tsukanov, Juan María Roldán-Romero, Chintan Mehta, Luca Fumis, Graham McNeill, James D Hayhurst, Ricardo Esteban Martinez Osorio, Ehsan Barkhordari, Javier Ferrer, Miguel Carmona, Prashant Uniyal, Maria J Falaguera, Polina Rusina, Ines Smit, Jeremy Schwartzentruber, Tobi Alegbe, Vivien W Ho, Daniel Considine, Xiangyu Ge, Szymon Szyszkowski, Yakov Tsepilov, Maya Ghoussaini, Ian Dunham, David G Hulcoop, Ellen M McDonagh, and David Ochoa · 2024
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Aviary: Training language agents on challenging scientific tasks, Dec 2024
Siddharth Narayanan, James D. Braza, Ryan-Rhys Griffiths, Manu Ponnapati, Albert Bou, Jon Laurent, Ori Kabeli, Geemi Wellawatte, Sam Cox, Samuel G. Rodriques, and et al · 2024
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Ripasudil as a Potential Therapeutic Agent in Treating Secondary Glaucoma in HTLV-1-Uveitis: An In Vitro Analysis
Mingming Yang, Koju Kamoi, Yuan Zong, Jing Zhang, Yaru Zou, and Kyoko Ohno-Matsui · 2024
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LitLLM: A Toolkit for Scientific Literature Review, March 2025
Shubham Agarwal, Gaurav Sahu, Abhay Puri, Issam H. Laradji, Krishnamurthy DJ Dvijotham, Jason Stanley, Laurent Charlin, and Christopher Pal · 2025
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Automated Hypothesis Validation with Agentic Sequential Falsifications, February 2025
Kexin Huang, Ying Jin, Ryan Li, Michael Y. Li, Emmanuel Candès, and Jure Leskovec · 2025
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TxGemma: Efficient and Agentic LLMs for Therapeutics, April 2025
Eric Wang, Samuel Schmidgall, Paul F. Jaeger, Fan Zhang, Rory Pilgrim, Yossi Matias, Joelle Barral, David Fleet, and Shekoofeh Azizi · 2025
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Towards an AI co-scientist, February 2025
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Bixbench: A comprehensive benchmark for llm-based agents in computational biology, Mar 2025
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2024 FDA approvals exceed average number but have lower sales projections
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