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Differential Diagnosis (DDx) is a fundamental yet complex aspect of clinical decision-making, in which physicians iteratively refine a ranked list of possible diseases based on symptoms, antecedents, and medical knowledge.
Analysis of questions asked by family doctors regarding patient care
John W Ely, Jerome A Osheroff, Mark H Ebell, George R Bergus, Barcey T Levy, M Lee Chambliss, and Eric R Evans. 1999 · 1999
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The patient history: An evidence-based approach to differential diagnosis
Mark C Henderson, Lawrence M Tierney Jr, and Gerald W Smetana. 2012 · 2012
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Formulating a Differential Diagnosis for the Advanced Practice Provider
Jacqueline Rhoads, Julie C Penick, et al. 2017 · 2017
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Publicly available clinical BERT embeddings
Emily Alsentzer, John Murphy, William Boag, Wei-Hung Weng, Di Jindi, Tristan Naumann, and Matthew McDermott. 2019 · 2019
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Higher order thinking about differential diagnosis
Chad E. Cook and Simon Décary. 2020 · 2020
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A Deep Learning System for Differential Diagnosis of Skin Diseases
Yuan Liu, Ayush Jain, Clara Eng, David H Way, Kang Lee, Peggy Bui, Kimberly Kanada, Guilherme de Oliveira Marinho, Jessica Gallegos, Sara Gabriele, et al. 2020 · 2020
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Differential Diagnosis of Common Etiologies of Left Ventricular Hypertrophy Using a Hybrid CNN-LSTM Model
In-Chang Hwang, Dongjun Choi, You-Jung Choi, Lia Ju, Myeongju Kim, Ji-Eun Hong, Hyun-Jung Lee, Yeonyee E Yoon, Jun-Bean Park, Seung-Pyo Lee, et al. 2022 · 2022
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Chain-of-thought prompting elicits reasoning in large language models
Jason Wei, Xuezhi Wang, Dale Schuurmans, Maarten Bosma, Fei Xia, Ed Chi, Quoc V Le, Denny Zhou, et al. 2022 · 2022
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DDxt: Deep generative transformer models for differential diagnosis
Mohammad Mahmudul Alam, Edward Raff, Tim Oates, and Cynthia Matuszek. 2023 · 2023
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Let‘s think frame by frame with VIP: A video infilling and prediction dataset for evaluating video chain-of-thought
Vaishnavi Himakunthala, Andy Ouyang, Daniel Rose, Ryan He, Alex Mei, Yujie Lu, Chinmay Sonar, Michael Saxon, and William Wang. 2023 · 2023
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ChatGPT-Generated Differential Diagnosis Lists for Complex Case–Derived Clinical Vignettes: Diagnostic Accuracy Evaluation
Takanobu Hirosawa, Ren Kawamura, Yukinori Harada, Kazuya Mizuta, Kazuki Tokumasu, Yuki Kaji, Tomoharu Suzuki, and Taro Shimizu. 2023 · 2023
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Towards Accurate Differential Diagnosis with Large Language Models
Daniel McDuff, Mike Schaekermann, Tao Tu, Anil Palepu, Amy Wang, Jake Garrison, Karan Singhal, Yash Sharma, Shekoofeh Azizi, Kavita Kulkarni, et al. 2023 · 2023
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Can generalist foundation models outcompete special-purpose tuning? case study in medicine
Harsha Nori, Yin Tat Lee, Sheng Zhang, Dean Carignan, Richard Edgar, Nicolo Fusi, Nicholas King, Jonathan Larson, Yuanzhi Li, Weishung Liu, et al. 2023 · 2023
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On the limitations of large language models in clinical diagnosis
Justin T Reese, Daniel Danis, J Harry Caufield, Tudor Groza, Elena Casiraghi, Giorgio Valentini, Christopher J Mungall, and Peter N Robinson. 2024 · 2023
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Visual chain of thought: bridging logical gaps with multimodal infillings
Daniel Rose, Vaishnavi Himakunthala, Andy Ouyang, Ryan He, Alex Mei, Yujie Lu, Michael Saxon, Chinmay Sonar, Diba Mirza, and William Yang Wang. 2023 · 2023
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Large language models perform diagnostic reasoning
Cheng-Kuang Wu, Wei-Lin Chen, and Hsin-Hsi Chen. 2023 · 2023
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React: Synergizing reasoning and acting in language models
Shunyu Yao, Jeffrey Zhao, Dian Yu, Nan Du, Izhak Shafran, Karthik R Narasimhan, and Yuan Cao. 2023 · 2023
Cited alongside, same era.
Rarebench: Can llms serve as rare diseases specialists?
Xuanzhong Chen, Xiaohao Mao, Qihan Guo, Lun Wang, Shuyang Zhang, and Ting Chen. 2024 · 2024
Cited alongside, same era.
Abhimanyu Dubey, Abhinav Jauhri, Abhinav Pandey, Abhishek Kadian, Ahmad Al-Dahle, Aiesha Letman, Akhil Mathur, Alan Schelten, Amy Yang, Angela Fan, et al. 2024 · 2024
Cited alongside, same era.
Evaluating gpt-4 as an academic support tool for clinicians: a comparative analysis of case records from the literature
B.L. Fabre, M.A.F. Magalhaes Filho, P.N. Aguiar, F.M. da Costa, B. Gutierres, W.N. William, and A. Del Giglio. 2024 · 2024
Cited alongside, same era.
MedMT5: An open-source multilingual text-to-text LLM for the medical domain
Iker García-Ferrero, Rodrigo Agerri, Aitziber Atutxa Salazar, Elena Cabrio, Iker de la Iglesia, Alberto Lavelli, Bernardo Magnini, Benjamin Molinet, Johana Ramirez-Romero, German Rigau, Jose Maria Villa-Gonzalez, Serena Villata, and Andrea Zaninello. 2024 · 2024
Evaluation of ChatGPT-Generated Differential Diagnosis for Common Diseases With Atypical Presentation: Descriptive Research
Kiyoshi Shikino, Taro Shimizu, Yuki Otsuka, Masaki Tago, Hiromizu Takahashi, Takashi Watari, Yosuke Sasaki, Gemmei Iizuka, Hiroki Tamura, Koichi Nakashima, et al. 2024 · 2024
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Conversational disease diagnosis via external planner-controlled large language models
Zhoujian Sun, Cheng Luo, Ziyi Liu, and Zhengxing Huang. 2024 · 2024
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MedAgents: Large language models as collaborators for zero-shot medical reasoning
Xiangru Tang, Anni Zou, Zhuosheng Zhang, Ziming Li, Yilun Zhao, Xingyao Zhang, Arman Cohan, and Mark Gerstein. 2024 · 2024
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ChatGPT and Generating a Differential Diagnosis Early in an Emergency Department Presentation
Hidde Ten Berg, Bram van Bakel, Lieke van de Wouw, Kim E Jie, Anoeska Schipper, Henry Jansen, Rory D O’Connor, Bram van Ginneken, and Steef Kurstjens. 2024 · 2024
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Cited alongside, same era.
AgentQuest: A modular benchmark framework to measure progress and improve LLM agents
Luca Gioacchini, Giuseppe Siracusano, Davide Sanvito, Kiril Gashteovski, David Friede, Roberto Bifulco, and Carolin Lawrence. 2024 · 2024
Cited alongside, same era.
Aaron Hurst, Adam Lerer, Adam P Goucher, Adam Perelman, Aditya Ramesh, Aidan Clark, AJ Ostrow, Akila Welihinda, Alan Hayes, Alec Radford, et al. 2024 · 2024
Cited alongside, same era.
CRAFT-MD: A conversational evaluation framework for comprehensive assessment of clinical LLMs
Shreya Johri, Jaehwan Jeong, Benjamin A. Tran, Daniel I Schlessinger, Shannon Wongvibulsin, Zhuo Ran Cai, Roxana Daneshjou, and Pranav Rajpurkar. 2024 · 2024
Cited alongside, same era.
Principles of diagnostic reasoning
Sallianne Kavanagh, Katie Van Der Tuijn, and Amie Bain. 2024 · 2024
Cited alongside, same era.
Mdagents: An adaptive collaboration of llms for medical decision-making
Yubin Kim, Chanwoo Park, Hyewon Jeong, Yik Siu Chan, Xuhai "Orson" Xu, Daniel McDuff, Hyeonhoon Lee, Marzyeh Ghassemi, Cynthia Breazeal, and Hae Park. 2024 · 2024
Cited alongside, same era.
Can chatgpt-4 evaluate whether a differential diagnosis list contains the correct diagnosis as accurately as a physician?
Kazuya Mizuta, Takanobu Hirosawa, Yukinori Harada, and Taro Shimizu. 2024 · 2024
Cited alongside, same era.
Few shot chain-of-thought driven reasoning to prompt LLMs for open-ended medical question answering
Saeel Sandeep Nachane, Ojas Gramopadhye, Prateek Chanda, Ganesh Ramakrishnan, Kshitij Sharad Jadhav, Yatin Nandwani, Dinesh Raghu, and Sachindra Joshi. 2024 · 2024
Cited alongside, same era.
Tao Tu, Anil Palepu, Mike Schaekermann, Khaled Saab, Jan Freyberg, Ryutaro Tanno, Amy Wang, Brenna Li, Mohamed Amin, Nenad Tomasev, et al. 2024 · 2024
Later among the works it cites.
Beyond direct diagnosis: Llm-based multi-specialist agent consultation for automatic diagnosis
Haochun Wang, Sendong Zhao, Zewen Qiang, Nuwa Xi, Bing Qin, and Ting Liu. 2024 · 2024
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DDxGym: Online transformer policies in a knowledge graph based natural language environment
Benjamin Winter, Alexei Gustavo Figueroa Rosero, Alexander Loeser, Felix Alexander Gers, Nancy Katerina Figueroa Rosero, and Ralf Krestel. 2024 · 2024
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Streambench: Towards benchmarking continuous improvement of language agents
Cheng-Kuang Wu, Zhi Rui Tam, Chieh-Yen Lin, Yun-Nung Chen, and Hung yi Lee. 2024 · 2024
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C-pack: Packed resources for general chinese embeddings
Shitao Xiao, Zheng Liu, Peitian Zhang, Niklas Muennighoff, Defu Lian, and Jian-Yun Nie. 2024 · 2024
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Rare disease diagnosis using knowledge guided retrieval augmentation for chatgpt
Charlotte Zelin, Wendy K Chung, Mederic Jeanne, Gongbo Zhang, and Chunhua Weng. 2024 · 2024
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Ultramedical: Building specialized generalists in biomedicine
Kaiyan Zhang, Sihang Zeng, Ermo Hua, Ning Ding, Zhang-Ren Chen, Zhiyuan Ma, Haoxin Li, Ganqu Cui, Biqing Qi, Xuekai Zhu, Xingtai Lv, Hu Jinfang, Zhiyuan Liu, and Bowen Zhou. 2024 · 2024
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Interpretable differential diagnosis with dual-inference large language models
Shuang Zhou, Mingquan Lin, Sirui Ding, Jiashuo Wang, Genevieve B Melton, James Zou, and Rui Zhang. 2024 · 2024
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Emerge: Integrating rag for improved multimodal ehr predictive modeling
Yinghao Zhu, Changyu Ren, Zixiang Wang, Xiaochen Zheng, Shiyun Xie, Junlan Feng, Xi Zhu, Zhoujun Li, Liantao Ma, and Chengwei Pan. 2024 · 2024
Later among the works it cites.
Kaiwen Zuo, Yirui Jiang, Fan Mo, and Pietro Lio. 2024 · 2024
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An evaluation framework for clinical use of large language models in patient interaction tasks
Shreya Johri, Jaehwan Jeong, Benjamin A Tran, Daniel I Schlessinger, Shannon Wongvibulsin, Leandra A Barnes, Hong-Yu Zhou, Zhuo Ran Cai, Eliezer M Van Allen, David Kim, et al. 2025 · 2025
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