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Agents based on large language models have shown great potential in accelerating scientific discovery by leveraging their rich background knowledge and reasoning capabilities.
Scientific discovery as problem solving
Herbert A. Simon, Pat Langley, and Gary L. Bradshaw · 1981
Earlier work this paper cites.
Scientific discovery: Computational explorations of the creative processes
Pat Langley, Herbert A. Simon, Gary L. Bradshaw, and Jan M. Zytkow · 1987
Earlier work this paper cites.
Functional genomic hypothesis generation and experimentation by a robot scientist
Ross D King, Kenneth E Whelan, Ffion M Jones, Philip GK Reiser, Christopher H Bryant, Stephen H Muggleton, Douglas B Kell, and Stephen G Oliver · 2004
Earlier work this paper cites.
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
Michael Kalos, Bruce L Levine, David L Porter, Sharyn Katz, Stephan A Grupp, Adam Bagg, and Carl H June · 2011
Earlier work this paper cites.
Going forward with genetics: recent technological advances and forward genetics in mice
Eva Marie Y Moresco, Xiaohong Li, and Bruce Beutler · 2013
Earlier work this paper cites.
Using next-generation sequencing to isolate mutant genes from forward genetic screens
Korbinian Schneeberger · 2014
Earlier work this paper cites.
The support of human genetic evidence for approved drug indications
Matthew R Nelson, Hannah Tipney, Jeffery L Painter, Judong Shen, Paola Nicoletti, Yufeng Shen, Aris Floratos, Pak Chung Sham, Mulin Jun Li, Junwen Wang, et al · 2015
Earlier work this paper cites.
Efficient generation of transcriptomic profiles by random composite measurements
Brian Cleary, Le Cong, Anthea Cheung, Eric S Lander, and Aviv Regev · 2017
Earlier work this paper cites.
Kegg: new perspectives on genomes, pathways, diseases and drugs
Minoru Kanehisa, Miho Furumichi, Mao Tanabe, Yoko Sato, and Kanae Morishima · 2017
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Defining a cancer dependency map
Aviad Tsherniak, Francisca Vazquez, Phil G Montgomery, Barbara A Weir, Gregory Kryukov, Glenn S Cowley, Stanley Gill, William F Harrington, Sasha Pantel, John M Krill-Burger, et al · 2017
Earlier work this paper cites.
Mapping the genetic landscape of human cells
Max A Horlbeck, Albert Xu, Min Wang, Neal K Bennett, Chong Y Park, Derek Bogdanoff, Britt Adamson, Eric D Chow, Martin Kampmann, Tim R Peterson, et al · 2018
Earlier work this paper cites.
Massive mining of publicly available rna-seq data from human and mouse
Alexander Lachmann, Denis Torre, Alexandra B. Keenan, Kathleen M. Jagodnik, Hoyjin J. Lee, Lily Wang, Moshe C. Silverstein, and Avi Ma’ayan · 2018
Earlier work this paper cites.
Genedisco: A benchmark for experimental design in drug discovery
Arash Mehrjou, Ashkan Soleymani, Andrew Jesson, Pascal Notin, Yarin Gal, Stefan Bauer, and Patrick Schwab · 2021
Earlier work this paper cites.
Genome-wide crispr screen identifies protein pathways modulating tau protein levels in neurons
Carlos G Sanchez, Christopher M Acker, Audrey Gray, Malini Varadarajan, Cheng Song, Nadire R Cochran, Steven Paula, Alicia Lindeman, Shaojian An, Gregory McAllister, et al · 2021
Earlier work this paper cites.
Rasa2 ablation in t cells boosts antigen sensitivity and long-term function
Julia Carnevale, Eric Shifrut, Nupura Kale, William A Nyberg, Franziska Blaeschke, Yan Yi Chen, Zhongmei Li, Sagar P Bapat, Morgan E Diolaiti, Patrick O’Leary, et al · 2022
Earlier work this paper cites.
The reactome pathway knowledgebase 2022
Marc Gillespie, Bijay Jassal, Ralf Stephan, Marija Milacic, Karen Rothfels, Andrea Senff-Ribeiro, Johannes Griss, Cristoffer Sevilla, Lisa Matthews, Chuqiao Gong, Chuan Deng, Thawfeek Varusai, Eliot Ragueneau, Yusra Haider, Bruce May, Veronica Shamovsky, Joel Weiser, Timothy Brunson, Nasim Sanati, Liam Beckman, Xiang Shao, Antonio Fabregat, Konstantinos Sidiropoulos, Julieth Murillo, Guilherme Viteri, Justin Cook, Solomon Shorser, Gary Bader, Emek Demir, Chris Sander, Robin Haw, Guanming Wu, Lincoln Stein, Henning Hermjakob, and Peter D’Eustachio · 2022
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Pooled screening of car t cells identifies diverse immune signaling domains for next-generation immunotherapies
Daniel B Goodman, Camillia S Azimi, Kendall Kearns, Alexis Talbot, Kiavash Garakani, Julie Garcia, Nisarg Patel, Byungjin Hwang, David Lee, Emily Park, et al · 2022
Earlier work this paper cites.
The emerging era of cell engineering: Harnessing the modularity of cells to program complex biological function
Wendell A Lim · 2022
Earlier work this paper cites.
A new era in functional genomics screens
Laralynne Przybyla and Luke A Gilbert · 2022
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Crispr activation and interference screens decode stimulation responses in primary human t cells
Ralf Schmidt, Zachary Steinhart, Madeline Layeghi, Jacob W Freimer, Raymund Bueno, Vinh Q Nguyen, Franziska Blaeschke, Chun Jimmie Ye, and Alexander Marson · 2022
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React: Synergizing reasoning and acting in language models
Shunyu Yao, Jeffrey Zhao, Dian Yu, Nan Du, Izhak Shafran, Karthik Narasimhan, and Yuan Cao · 2022
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Introducing claude, 2023
Anthropic · 2023
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AutoGPT: An experimental open-source attempt to make gpt-4 fully autonomous
AutoGPT · 2023
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Autonomous chemical research with large language models
Daniil A Boiko, Robert MacKnight, Ben Kline, and Gabe Gomes · 2023
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An spns1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation
Samantha G Scharenberg, Wentao Dong, Ali Ghoochani, Kwamina Nyame, Roni Levin-Konigsberg, Aswini R Krishnan, Eshaan S Rawat, Kaitlyn Spees, Michael C Bassik, and Monther Abu-Remaileh · 2023
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Toolformer: Language models can teach themselves to use tools (2023)
Timo Schick, Jane Dwivedi-Yu, R Dessı, Roberta Raileanu, Maria Lomeli, Luke Zettlemoyer, Nicola Cancedda, and Thomas Scialom · 2023
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Experimental evidence on the productivity effects of generative artificial intelligence
Noy Shakked and Whitney Zhang · 2023
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Reflexion: an autonomous agent with dynamic memory and self-reflection
Noah Shinn, Beck Labash, and Ashwin Gopinath · 2023
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Scientific discovery in the age of artificial intelligence
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Yiqun T Chen and James Zou · 2023
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Geneturing tests gpt models in genomics
Wenpin Hou and Zhicheng Ji · 2023
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Evaluation of large language models for discovery of gene set function
Mengzhou Hu, Sahar Alkhairy, Ingoo Lee, Rudolf T Pillich, Robin Bachelder, Trey Ideker, and Dexter Pratt · 2023
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Sequential optimal experimental design of perturbation screens guided by multi-modal priors
Kexin Huang, Romain Lopez, Jan-Christian Hutter, Takamasa Kudo, Antonio Rios, and Aviv Regev · 2023
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Paperqa: Retrieval-augmented generative agent for scientific research
Jakub Lála, Odhran O’Donoghue, Aleksandar Shtedritski, Sam Cox, Samuel G Rodriques, and Andrew D White · 2023
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Chatgpt-powered conversational drug editing using retrieval and domain feedback
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Discobax discovery of optimal intervention sets in genomic experiment design
Clare Lyle, Arash Mehrjou, Pascal Notin, Andrew Jesson, Stefan Bauer, Yarin Gal, and Patrick Schwab · 2023
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Hanchen Wang, Tianfan Fu, Yuanqi Du, Wenhao Gao, Kexin Huang, Ziming Liu, Payal Chandak, Shengchao Liu, Peter Van Katwyk, Andreea Deac, et al · 2023
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Crispr technology: A decade of genome editing is only the beginning
Joy Y Wang and Jennifer A Doudna · 2023
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Large language models are better reasoners with self-verification, 2023
Yixuan Weng, Minjun Zhu, Fei Xia, Bin Li, Shizhu He, Kang Liu, and Jun Zhao · 2023
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Empowering biomedical discovery with ai agents
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Assessing gpt-4 for cell type annotation in single-cell rna-seq analysis
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Crispr-gpt: An llm agent for automated design of gene-editing experiments
Kaixuan Huang, Yuanhao Qu, Henry Cousins, William A Johnson, Di Yin, Mihir Shah, Denny Zhou, Russ Altman, Mengdi Wang, and Le Cong · 2024
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Genegpt: Augmenting large language models with domain tools for improved access to biomedical information
Qiao Jin, Yifan Yang, Qingyu Chen, and Zhiyong Lu · 2024
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Lab-bench: Measuring capabilities of language models for biology research
Jon M Laurent, Joseph D Janizek, Michael Ruzo, Michaela M Hinks, Michael J Hammerling, Siddharth Narayanan, Manvitha Ponnapati, Andrew D White, and Samuel G Rodriques · 2024
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Chatgpt as research scientist: Probing gpt’s capabilities as a research librarian, research ethicist, data generator, and data predictor
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Large language models to enhance bayesian optimization
Tennison Liu, Nicolás Astorga, Nabeel Seedat, and Mihaela van der Schaar · 2024
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Augmenting large language models with chemistry tools
Andres M. Bran, Sam Cox, Oliver Schilter, Carlo Baldassari, Andrew D White, and Philippe Schwaller · 2024
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Toolformer: Language models can teach themselves to use tools
Timo Schick, Jane Dwivedi-Yu, Roberto Dessì, Roberta Raileanu, Maria Lomeli, Eric Hambro, Luke Zettlemoyer, Nicola Cancedda, and Thomas Scialom · 2024
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Self-driving laboratories for chemistry and materials science
Gary Tom, Stefan P Schmid, Sterling G Baird, Yang Cao, Kourosh Darvish, Han Hao, Stanley Lo, Sergio Pablo-García, Ella M Rajaonson, Marta Skreta, et al · 2024
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pymed - pubmed querying with python, 2020
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Zero-shot clinical trial patient matching with llms
Michael Wornow, Alejandro Lozano, Dev Dash, Jenelle Jindal, Kenneth W Mahaffey, and Nigam H Shah · 2024
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