2022

Generation of Anonymous Chest Radiographs Using Latent Diffusion Models for Training Thoracic Abnormality Classification Systems

Packhäuser, Kai, Folle, Lukas, Thamm, Florian et al.

Understand

The availability of large-scale chest X-ray datasets is a requirement for developing well-performing deep learning-based algorithms in thoracic abnormality detection and classification.

  • However, biometric identifiers in chest radiographs hinder the public sharing of such data for research purposes due to the risk of patient re-identification.
  • To counteract this issue, synthetic data generation offers a solution for anonymizing medical images.
  • This work employs a latent diffusion model to synthesize an anonymous chest X-ray dataset of high-quality class-conditional images.

Built on

  • “Adam: A Method for Stochastic Optimization,”

    Original

    Diederik P Kingma and Jimmy Ba, · 2014

    Earlier work this paper cites.

  • “Deep Unsupervised Learning using Nonequilibrium Thermodynamics,”

    Jascha Sohl-Dickstein, Eric Weiss, Niru Maheswaranathan, and Surya Ganguli, · 2015

    Earlier work this paper cites.

  • “CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning,”

    Original

    Pranav Rajpurkar et al., · 2017

    Earlier work this paper cites.

  • “Densely Connected Convolutional Networks,”

    Gao Huang, Zhuang Liu, Laurens Van Der Maaten, and Kilian Q Weinberger, · 2017

    Earlier work this paper cites.

  • “Learning to Recognize Abnormalities in Chest X-Rays with Location-Aware Dense Networks,”

    Sebastian Gündel, Sasa Grbic, Bogdan Georgescu, Siqi Liu, Andreas Maier, and Dorin Comaniciu, · 2018

    Earlier work this paper cites.

  • “Progressive Growing of GANs for Improved Quality, Stability, and Variation,”

    Tero Karras, Timo Aila, Samuli Laine, and Jaakko Lehtinen, · 2018

    Earlier work this paper cites.

Similar

  • “cGANs with Projection Discriminator,”

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  • “The Unreasonable Effectiveness of Deep Features as a Perceptual Metric,”

    Richard Zhang, Phillip Isola, Alexei A Efros, Eli Shechtman, and Oliver Wang, · 2018

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  • “A gentle introduction to deep learning in medical image processing,”

    Andreas Maier, Christopher Syben, Tobias Lasser, and Christian Riess, · 2019

    Cited alongside, same era.

  • “Breaking medical data sharing boundaries by using synthesized radiographs,”

    Tianyu Han et al., · 2020

    Cited alongside, same era.

  • “Towards Improving Privacy of Synthetic DataSets,”

    Aditya Kuppa, Lamine Aouad, and Nhien-An Le-Khac, · 2021

    Cited alongside, same era.

Then

  • “Taming Transformers for High-Resolution Image Synthesis,”

    Patrick Esser, Robin Rombach, and Björn Ommer, · 2021

    Later among the works it cites.

  • “Deep learning-based patient re-identification is able to exploit the biometric nature of medical chest X-ray data,”

    Kai Packhäuser, Sebastian Gündel, Nicolas Münster, Christopher Syben, Vincent Christlein, and Andreas Maier, · 2022

    Closest in time.

  • “Adapting Pretrained Vision-Language Foundational Models to Medical Imaging Domains,”

    Original

    Pierre Chambon, Christian Bluethgen, Curtis P Langlotz, and Akshay Chaudhari, · 2022

    Closest in time.

  • “High-Resolution Image Synthesis with Latent Diffusion Models,”

    Robin Rombach, Andreas Blattmann, Dominik Lorenz, Patrick Esser, and Björn Ommer, · 2022

    Closest in time.

  • “ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases,”

    Xiaosong Wang, Yifan Peng, Le Lu, Zhiyong Lu, Mohammadhadi Bagheri, and Ronald M Summers, · 2097

    Closest in time.

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