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We set the strongest limits to-date on the velocity-independent dark matter (DM) - proton cross section $\sigma$ for DM masses $m = 10\,\mathrm{keV}$ to $100\,\mathrm{GeV}$, using large-scale structure traced by the Lyman-alpha forest: e.g., a 95% lower limit $\sigma < 6 \times 10^{-30}\,\mathrm{cm}^2$, for $m = 100\,\mathrm{keV}$.
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