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In data analysis problems where we are not able to rely on distributional assumptions, what types of inference guarantees can still be obtained? Many popular methods, such as holdout methods, cross-validation methods, and conformal prediction, are able to provide distribution-free guarantees for predictive inference, but the problem of providing inference for the underlying regression function (for example, inference on the conditional mean $\mathbb{E}[Y|X]$) is more challenging.
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