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By directly inverting several neutron star observables in the three-dimensional parameter space for the Equation of State of super-dense neutron-rich nuclear matter, we show that the lower radius limit for PSR J0740+6620 of mass $2.08\pm 0.07~M_{\odot}$ from Neutron Star Interior Composition Explorer (NICER)'s very recent observation sets a much tighter lower boundary than previously known for nuclear symmetry energy in the density range of $(1.0\sim 3.0)$ times the saturation density $\rho_0$ of nuclear matter.
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