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It is known that three fundamental questions regarding local Hamiltonians -- approximating the ground state energy (the Local Hamiltonian problem), simulating local measurements on the ground space (APX-SIM), and deciding if the low energy space has an energy barrier (GSCON) -- are $\mathsf{QMA}$-hard, $\mathsf{P}^{\mathsf{QMA}[log]}$-hard and $\mathsf{QCMA}$-hard, respectively, meaning they are likely intractable even on a quantum computer.
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