DeepFoldit -- A Deep Reinforcement Learning Neural Network Folding Proteins

Understand

Despite considerable progress, ab initio protein structure prediction remains suboptimal.

• A crowdsourcing approach is the online puzzle video game Foldit, that provided several useful results that matched or even outperformed algorithmically computed solutions.
• Using Foldit, the WeFold crowd had several successful participations in the Critical Assessment of Techniques for Protein Structure Prediction.
• Based on the recent Foldit standalone version, we trained a deep reinforcement neural network called DeepFoldit to improve the score assigned to an unfolded protein, using the Q-learning method with experience replay.