Assigning function to protein-protein interactions: a weakly supervised BioBERT based approach using PubMed abstracts

Understand

Motivation: Protein-protein interactions (PPI) are critical to the function of proteins in both normal and diseased cells, and many critical protein functions are mediated by interactions.Knowledge of the nature of these interactions is important for the construction of networks to analyse biological data.

• However, only a small percentage of PPIs captured in protein interaction databases have annotations of function available, e.g.
• only 4% of PPI are functionally annotated in the IntAct database.
• Here, we aim to label the function type of PPIs by extracting relationships described in PubMed abstracts.