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We point out that in models of macroscopic topological defects composed of one or more scalar fields that interact with standard-model fields via scalar-type couplings, the back-action of ambient matter on the scalar field(s) produces an environmental dependence of the fundamental constants of nature, as well as spatial variations of the fundamental constants in the vicinity of dense bodies such as Earth due to the formation of a "bubble-like" defect structure surrounding the dense body.
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