A predictive structural model of the primate connectome

Understand

Anatomical connectivity imposes strong constraints on brain function, but there is no general agreement about principles that govern its organization.

• Based on extensive quantitative data we tested the power of three models to predict connections of the primate cerebral cortex: architectonic similarity (structural model), spatial proximity (distance model) and thickness similarity (thickness model).
• Architectonic similarity showed the strongest and most consistent influence on connection features.
• This parameter was strongly associated with the presence or absence of inter-areal connections and when integrated with spatial distance, the model allowed predicting the existence of projections with very high accuracy.