Moduli Spaces of Phylogenetic Trees Describing Tumor Evolutionary Patterns

Understand

Cancers follow a clonal Darwinian evolution, with fitter subclones replacing more quiescent cells, ultimately giving rise to macroscopic disease.

• High-throughput genomics provides the opportunity to investigate these processes and determine specific genetic alterations driving disease progression.
• Genomic sampling of a patient's cancer provides a molecular history, represented by a phylogenetic tree.
• Cohorts of patients represent a forest of related phylogenetic structures.