Finding low-energy conformations of lattice protein models by quantum annealing

Understand

Lattice protein folding models are a cornerstone of computational biophysics.

• Although these models are a coarse grained representation, they provide useful insight into the energy landscape of natural proteins.
• Finding low-energy three-dimensional structures is an intractable problem even in the simplest model, the Hydrophobic-Polar (HP) model.
• Exhaustive search of all possible global minima is limited to sequences in the tens of amino acids.