The distribution of cycles in breakpoint graphs of signed permutations

Understand

Breakpoint graphs are ubiquitous structures in the field of genome rearrangements.

• Their cycle decomposition has proved useful in computing and bounding many measures of (dis)similarity between genomes, and studying the distribution of those cycles is therefore critical to gaining insight on the distributions of the genomic distances that rely on it.
• We extend here the work initiated by Doignon and Labarre, who enumerated unsigned permutations whose breakpoint graph contains $k$ cycles, to signed permutations, and prove explicit formulas for computing the expected value and the variance of the corresponding distributions, both in the unsigned case and in the signed case.
• We also compare these distributions to those of several well-studied distances, emphasising the cases where approximations obtained in this way stand out.